Brain damage after intermittent partial cord occlusion in the chronically instrumented fetal lamb

The relationship between intermittent partial occlusion of the umbilical circulation and fetal acid base status, brain function, and neuropathologic outcome was assessed in nine control and nine experimental singleton fetal lambs to determine if transient episodes of partial cord occlusion play a ro...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 159; no. 2; p. 504
Main Authors Clapp, J F, Peress, N S, Wesley, M, Mann, L I
Format Journal Article
LanguageEnglish
Published United States 01.08.1988
Subjects
Acid-Base Equilibrium
Animals
Blood Circulation
Blood Gas Analysis
Blood Pressure
Brain Damage, Chronic - etiology
Brain Damage, Chronic - pathology
Constriction
Double-Blind Method
Electroencephalography
Female
Fetal Diseases - etiology
Fetal Diseases - pathology
Heart Rate, Fetal
Pregnancy
Sheep
Umbilical Cord - blood supply
Vascular Diseases - complications
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Summary:The relationship between intermittent partial occlusion of the umbilical circulation and fetal acid base status, brain function, and neuropathologic outcome was assessed in nine control and nine experimental singleton fetal lambs to determine if transient episodes of partial cord occlusion play a role in antenatal brain damage in this species. Intermittent partial occlusion of the umbilical circulation for 1 minute of every 3 minutes for 2 hours was associated with a 89% incidence of histologically confirmed damage confined to the cerebral white matter. This occurred without systemic evidence of progressive acidosis, but both fetal heart rate patterns and electrocortical activity were altered. We conclude that in the late gestation fetal lamb, umbilical cord compromise plays a causal role in a specific type of antenatal central nervous system injury.
ISSN:0002-9378
DOI:10.1016/s0002-9378(88)80118-2