Revealing the functions of TFIIB

The TFIIB linker domain stimulates the catalytic activity of archaeal RNAP. By characterising a range of super-stimulating mutants we identified a novel rate-limiting step in transcription initiation. Our results help to interpret structural findings and pave the way towards higher-resolution struct...

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Published inTranscription Vol. 2; no. 6; pp. 254 - 257
Main Authors Weinzierl, Robert O.J., Wiesler, Simone C.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.11.2011
Landes Bioscience
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Summary:The TFIIB linker domain stimulates the catalytic activity of archaeal RNAP. By characterising a range of super-stimulating mutants we identified a novel rate-limiting step in transcription initiation. Our results help to interpret structural findings and pave the way towards higher-resolution structures of the RNAP-TFIIB linker interface.
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ISSN:2154-1264
2154-1272
DOI:10.4161/trns.2.6.18076