Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls

• Published in: British journal of cancer Vol. 99; no. 10; pp. 1668 - 1672
• Main Authors: Vasconcelos, G M, Kang, M, Pombo-de-Oliveira, M S, Schiffman, J D, Lorey, F, Buffler, P, Wiemels, J L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.11.2008; Nature Publishing Group
• Subjects: Adenoviridae - isolation & purification; Adenoviridae Infections - blood; Adenoviridae Infections - virology; Adenovirus; Adenoviruses; Adolescent; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Child; Child, Preschool; Cloning; DNA methylation; DNA, Viral - blood; DNA, Viral - isolation & purification; Drug Resistance; Epidemiology; Fetuses; Hematologic and hematopoietic diseases; Hit & run accidents; Humans; Hypotheses; Infant; Infant, Newborn; Infections; Leukemia; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical research; Medical sciences; Molecular Diagnostics; Molecular Medicine; Oncology; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - virology; Public health; Tumors; Viruses; United States > US; San Francisco California; California; childhood leukaemia; prenatal infection; Guthrie card; viral aetiology; adenovirus; Human; Adenoviridae; Leukemia; Malignant hemopathy; Case control study; Card; Virus; Infection; Prenatal; Cancerology; Etiology; Viral disease; Diagnosis; Child; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6604714

Archived neonatal blood cards (Guthrie cards) from children who later contracted leukaemia and matched normal controls were assayed for adenovirus (AdV) C DNA content using two highly sensitive methods. In contrast to a previous report, AdV DNA was not detected at a higher frequency among neonates who later developed leukaemia, when compared with controls.