Effect of CYP3A53 on asthma control among children treated with inhaled beclomethasone

[...]the relative contributions of these SNPs to the clinical effects we observed could not be differentiated, although it is well known that CYP3A5*3 causes an alternative splicing event that results in nonfunctional CYP3A5 protein.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 136; no. 2; pp. 505 - 507
Main Authors Stockmann, Chris, MSc, Reilly, Christopher A., PhD, Fassl, Bernhard, MD, Gaedigk, Roger, PhD, Nkoy, Flory, MD, MPH, MS, Stone, Bryan, MD, Roberts, Jessica K., PhD, Uchida, Derek A., MD, Leeder, J. Steven, PharmD, PhD, Sherwin, Catherine M.T., PhD, Spigarelli, Michael G., MD, PhD, Yost, Garold S., PhD, Ward, Robert M., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2015
Elsevier Limited
Subjects
Administration, Inhalation
Adolescent
Allergy and Immunology
Anti-Asthmatic Agents - therapeutic use
Aryl Hydrocarbon Hydroxylases - genetics
Aryl Hydrocarbon Hydroxylases - immunology
Asthma - drug therapy
Asthma - genetics
Asthma - immunology
Asthma - pathology
Beclomethasone - therapeutic use
Child
Child, Preschool
Cytochrome P-450 CYP3A - genetics
Cytochrome P-450 CYP3A - immunology
Disease Management
Enzymes
Female
Gene Expression
Genotype & phenotype
Humans
Male
Patients
Polymorphism, Single Nucleotide
Studies
Treatment Outcome
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More Information
Summary:[...]the relative contributions of these SNPs to the clinical effects we observed could not be differentiated, although it is well known that CYP3A5*3 causes an alternative splicing event that results in nonfunctional CYP3A5 protein.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
Deceased
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.02.009