Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

• Published in: Nutrients Vol. 12; no. 5; p. 1539
• Main Authors: Yang, Jinwoo, Lee, Junsoo, Kim, Younghwa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2020; MDPI
• Subjects: Adipocytes; Adipocytes - drug effects; Adipose Tissue - drug effects; Adipose Tissue - metabolism; aglycone; Alanine Transaminase - blood; Animals; Anti-Obesity Agents - pharmacology; Aspartate Aminotransferases - blood; Blood Urea Nitrogen; Body weight; Body weight gain; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Creatinine - blood; deglycosylation; Diabetes; Diet; Diet, High-Fat; Flavonoids; Food; High fat diet; Hydrolysis; Hyperlipidemia; Hyperlipidemias - blood; Hyperlipidemias - drug therapy; Kinases; Lipids; Liver; Liver - drug effects; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Obesity - blood; Obesity - drug therapy; Oxidative stress; Plant Extracts - pharmacology; Quercetin; Risk analysis; Risk factors; Rutin; Rutin - pharmacology; Triglycerides; Triglycerides - blood; Variance analysis; Weight control; Weight Gain; United States > US; aglycone; quercetin; deglycosylation; rutin; obesity
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12051539

The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) groups compared to that in the HFD group. The adipocytes' size in epididymal fat in AR and Q groups was significantly reduced compared to that in the HFD group ( < 0.05). Treatment with AR decreased the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol compared to the HFD group. In particular, administration of AR significantly decreased serum triglyceride (36.82 mg/dL) by 46% compared to HFD (69.30 mg/dL). The AR group also showed significantly decreased atherogenic indices and cardiac risk factors. These results suggest that deglycosylated rutin generated by acid treatment enhances the anti-obesity and hypolipidemic effects in obese mice, and provides valuable information for improving the functional properties of glycosidic flavonoids.