Mechanisms of apoptotic phosphatidylserine exposure

It has been a long-standing enigma which scramblase causes phosphati- dylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recogni- tion, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that...

Full description

Saved in:
Bibliographic Details
Published inCell research Vol. 23; no. 11; pp. 1247 - 1248
Main Authors Mariño, Guillermo, Kroemer, Guido
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2013
Nature Publishing Group
Subjects
631/80/82/23
631/80/86
Animals
Biomedical and Life Sciences
Calcium - metabolism
Cell Biology
Cell Membrane - metabolism
Humans
Life Sciences
Phospholipid Transfer Proteins - metabolism
Phospholipids - metabolism
Research Highlight
凋亡细胞
同源基因
吞噬
机制
磷脂酰丝氨酸
线虫
细胞凋亡
酶裂解
Online AccessGet full text
ISSN1001-0602
1748-7838
1748-7838
DOI10.1038/cr.2013.115

Cover

More Information
Summary:It has been a long-standing enigma which scramblase causes phosphati- dylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recogni- tion, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.
Bibliography:31-1568/Q
It has been a long-standing enigma which scramblase causes phosphati- dylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recogni- tion, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Commentary-3
content type line 23
ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2013.115