Prostacyclin mediates antiaggregatory and hypotensive actions of endothelin in anaesthetized beagle dogs

• Published in: British journal of pharmacology Vol. 98; no. 1; pp. 38 - 40
• Main Authors: Hermán, Ferenc, Magyar, Kálmán, Chabrier, Pierre‐Etienne, Braquet, Pierre, Filep, János
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.1989; Nature Publishing
• Subjects: 6-Ketoprostaglandin F1 alpha - pharmacology; Anesthesia; Animals; Antihypertensive Agents; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Dogs; Dose-Response Relationship, Drug; Endothelins; Epoprostenol - physiology; Female; Injections, Intravenous; Male; Medical sciences; Peptides - pharmacology; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors; platelets; prostacyclin; Fissipedia; Carnivora; Endothelin; Intravenous administration; Peptides; Prostaglandin I2; Arachidonic acid derivatives; Antiplatelet agent; Aggregation; Vertebrata; Platelet; Mammalia; Animal; Antihypertensive agent; Blood pressure; Hemodynamics; Dog
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/j.1476-5381.1989.tb16859.x

The effects of endothelin on blood pressure and in vivo aggregation of platelets were studied in anaesthetized beagle dogs. Intravenous administration of endothelin (0.03‐0.3 nmol kg−1) resulted in a dose‐dependent transient hypotension followed by a long‐lasting hypertension and inhibition of platelet aggregation. These changes were accompanied by dose‐dependent elevation of plasma 6‐keto prostaglandin F1α levels. Pretreatment of the animals with acetylsalicylic acid significantly attenuated both the vascular and antiaggregatory responses to endothelin. These data provide evidence for in vivo release of prostacyclin by endothelin in anaesthetized dogs.