The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease
Long‐lived humoral immune responses are a hallmark of thymus‐dependent immunity. The cellular basis for enduring antibody‐mediated immunity is long‐lived memory B cells and plasma cells (PCs). Both of these cell populations acquire longevity as a result of antigen‐specific, CD40–dependent, cognate i...
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Published in | Immunological reviews Vol. 194; no. 1; pp. 61 - 76 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Munksgaard International Publishers
01.08.2003
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Subjects | |
Online Access | Get full text |
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Summary: | Long‐lived humoral immune responses are a hallmark of thymus‐dependent immunity. The cellular basis for enduring antibody‐mediated immunity is long‐lived memory B cells and plasma cells (PCs). Both of these cell populations acquire longevity as a result of antigen‐specific, CD40–dependent, cognate interactions with helper T cells within germinal centers (GCs). At the molecular level, defined functional domains of CD40 control the post‐GC fate of B cells. PC precursors that emerge from these GC reactions are highly proliferative and terminally differentiate to end‐stage cells within the bone marrow (BM). The striking phenotypic similarities between the PC precursors and the putative malignant cell in multiple myeloma (MM) suggests that MM may result from the transformation of PC precursors. Within the domain of autoimmune disease, recent studies have shown that dysregulated migration of PCs to the BM may impact immune homeostasis and the development of lupus. Understanding the processes of normal PC differentiation will provide strategic insights into identifying therapeutic targets for the treatment of differentiated B‐cell disorders. |
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Bibliography: | ark:/67375/WNG-QRSGWNF8-0 istex:26F1577654AE6BBA417E47B9EB7A645A7224913A ArticleID:IMR055 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0105-2896 1600-065X |
DOI: | 10.1034/j.1600-065X.2003.00055.x |