Genetic and molecular mapping of the Hmt region of mouse

• Published in: The EMBO journal Vol. 8; no. 12; pp. 3749 - 3757
• Main Authors: Richards, S., Bucan, M., Brorson, K., Kiefer, M.C., Hunt, S.W., Lehrach, H., Lindahl, K.F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.12.1989
• Subjects: Amino Acid Sequence; Animals; Antigens, Surface - genetics; Biological and medical sciences; Chromosome Mapping; Cloning, Molecular; DNA Probes; Fundamental and applied biological sciences. Psychology; Genes, MHC Class I; Genes. Genome; Genetic Linkage; Histocompatibility Antigens Class I - genetics; Major Histocompatibility Complex; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Recombination, Genetic; Restriction Mapping; Sequence Homology, Nucleic Acid; Thy-1 Antigens; Genetic mapping; Molecular hybridization; Genome organization; Major histocompatibility system; Rodentia; Chromosome; Vertebrata; Immunogenetics; Mammalia; Gene; Mouse; DNA; Restriction map; Southern blotting; Class I histocompatibility antigen
• ISSN: 0261-4189; 1460-2075
• DOI: 10.1002/j.1460-2075.1989.tb08551.x

We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx‐1, thus including Pgk‐2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk‐2, within the distal inversion in t‐haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.