Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer's Disease Brain and Olfactory Epithelium

• Published in: ChemMedChem Vol. 8; no. 6; pp. 891 - 897
• Main Authors: Gu, Jiamin, Anumala, Upendra Rao, Heyny-von Haußen, Roland, Hölzer, Jana, Goetschy-Meyer, Valérie, Mall, Gerhard, Hilger, Ingrid, Czech, Christian, Schmidt, Boris
• Format: Journal Article
• Language: English; German
• Published: Weinheim WILEY-VCH Verlag 01.06.2013; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Aged; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Brain - metabolism; Brain - pathology; Carbocyanines - chemical synthesis; Carbocyanines - chemistry; Carbocyanines - pharmacology; Cell Proliferation - drug effects; Chemistry, Medicinal; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - pharmacology; Hep G2 Cells; Humans; imaging agents; Life Sciences & Biomedicine; Male; Molecular Structure; neurodegenerative diseases; neurofibrillary tangles; olfactory epithelium; Olfactory Mucosa - chemistry; Olfactory Mucosa - metabolism; Olfactory Mucosa - pathology; Pharmacology & Pharmacy; Science & Technology; Structure-Activity Relationship; tau Proteins - analysis; Zebrafish - embryology; neurodegenerative diseases; AMYLOID-BETA; neurofibrillary tangles; IN-VIVO; olfactory epithelium; AGENTS; imaging agents; PATHOLOGY; PLAQUES; Alzheimer's disease; BINDING
• ISSN: 1860-7179; 1860-7187
• DOI: 10.1002/cmdc.201300090

Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post‐mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.