MRI reduces variation of contouring for boost clinical target volume in breast cancer patients without surgical clips in the tumour bed

• Published in: Radiology and oncology Vol. 51; no. 2; pp. 160 - 168
• Main Authors: Al-Hammadi, Noora, Caparrotti, Palmira, Divakar, Saju, Riyas, Mohamed, Chandramouli, Suparna Halsnad, Hammoud, Rabih, Hayes, Jillian, Mc Garry, Maeve, Paloor, Satheesh Prasad, Petric, Primoz
• Format: Journal Article
• Language: English
• Published: Poland De Gruyter Open 01.06.2017; De Gruyter Poland; Sciendo
• Subjects: Accuracy; Breast cancer; Cancer; Chemical vapor synthesis; Clips; Computed tomography; Contouring; contouring variation; Delineation; Image processing; Image segmentation; Lumpectomy; Magnetic resonance imaging; Mastectomy; MRI; Patients; Radiation; Radiation therapy; Surgery; Tumors; Visualization; contouring variation; CT; breast cancer; MRI; contouring
• ISSN: 1318-2099; 1581-3207; 1581-3207; 0485-893X
• DOI: 10.1515/raon-2017-0014

Omitting the placement of clips inside tumour bed during breast cancer surgery poses a challenge for delineation of lumpectomy cavity clinical target volume (CTV ). We aimed to quantify inter-observer variation and accuracy for CT- and MRI-based segmentation of CTV in patients without clips. CT- and MRI-simulator images of 12 breast cancer patients, treated by breast conserving surgery and radiotherapy, were included in this study. Five radiation oncologists recorded the cavity visualization score (CVS) and delineated CTV on both modalities. Expert-consensus (EC) contours were delineated by a senior radiation oncologist, respecting opinions of all observers. Inter-observer volumetric variation and generalized conformity index (CI ) were calculated. Deviations from EC contour were quantified by the accuracy index (AI) and inter-delineation distances (IDD). Mean CVS was 3.88 +/- 0.99 and 3.05 +/- 1.07 for MRI and CT, respectively (p = 0.001). Mean volumes of CTV were similar: 154 +/- 26 cm on CT and 152 +/- 19 cm on MRI. Mean CI and AI were superior for MRI when compared with CT (CI : 0.74 +/- 0.07 vs. 0.67 +/- 0.12, p = 0.007; AI: 0.81 +/- 0.04 vs. 0.76 +/- 0.07; p = 0.004). CI and AI increased with increasing CVS. Mean IDD was 3 mm +/- 1.5 mm and 3.6 mm +/- 2.3 mm for MRI and CT, respectively (p = 0.017). When compared with CT, MRI improved visualization of post-lumpectomy changes, reduced interobserver variation and improved the accuracy of CTV contouring in patients without clips in the tumour bed. Further studies with bigger sample sizes are needed to confirm our findings.