A Randomized Comparison of Paclitaxel-Eluting Stents Versus Bare-Metal Stents for Treatment of Unprotected Left Main Coronary Artery Stenosis

• Published in: Journal of the American College of Cardiology Vol. 50; no. 6; pp. 491 - 497
• Main Authors: Erglis, Andrejs, MD, PhD, FESC, FACC, Narbute, Inga, MD, Kumsars, Indulis, MD, Jegere, Sanda, MD, Mintale, Iveta, MD, Zakke, Ilja, MD, FESC, Strazdins, Uldis, MD, Saltups, Andris, MD, FACC, FRACP, MRACP
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.08.2007; Elsevier Limited
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary - instrumentation; Antineoplastic Agents, Phytogenic - administration & dosage; Blood Vessel Prosthesis Implantation - instrumentation; Cardiology; Cardiovascular; Coronary Angiography; Coronary Restenosis - prevention & control; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - pathology; Coronary Stenosis - therapy; Coronary Thrombosis - prevention & control; Coronary vessels; Coronary Vessels - pathology; Drug Delivery Systems; Female; Humans; Internal Medicine; Male; Medical imaging; Middle Aged; Paclitaxel - administration & dosage; Stents; Treatment Outcome; Ultrasonography, Interventional; LCX; LM; intravascular ultrasound; MLA; MLD; percutaneous coronary intervention; cutting balloon; left circumflex; quantitative coronary analysis; TLR; coronary artery bypass grafting; CB; bare-metal stent(s); target lesion revascularization; BMS; IVUS; left main; LAD; minimal lumen diameter; QCA; minimum lumen area; left anterior descending; paclitaxel-eluting stent(s); PCI; CABG; PES
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.03.055

A Randomized Comparison of Paclitaxel-Eluting Stents Versus Bare Metal Stents for Treatment of Unprotected Left Main Coronary Artery Stenosis Andrejs Erglis, Inga Narbute, Indulis Kumsars, Sanda Jegere, Iveta Mintale, Ilja Zakke, Uldis Strazdins, Andris Saltups To optimize percutaneous coronary intervention for unprotected left main (LM) disease we randomized intravascular ultrasound-guided bare metal stent (BMS; (n = 50) or paclitaxel-eluting stent (PES; n = 53) implantation after lesion pre-treatment with cutting balloon for unprotected LM lesions. Stent implantation was successful in all lesions. At 6 months’ follow-up, statistically significant benefits were observed in minimal lumen diameter late loss, in minimal lumen area late loss and neointimal volume for PES. At 6 months, major adverse cardiac event-free survival rate was 70% in the BMS group and 87% in the PES group (p = 0.036). Findings of this study demonstrate PES superiority to BMS in unprotected LM vessel.