DNA methylation in repetitive elements and Alzheimer disease

Research highlights ► DNA methylation is able to modify genome function and chromosomal stability. ► DNA methylation patterns is mainly determined by repetitive elements methylation. ► LINE-1 was increased in AD patients compared with healthy volunteers.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 25; no. 6; pp. 1078 - 1083
Main Authors Bollati, V, Galimberti, D, Pergoli, L, Dalla Valle, E, Barretta, F, Cortini, F, Scarpini, E, Bertazzi, P.A, Baccarelli, A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.08.2011
Subjects
Aged
Aged, 80 and over
Allergy and Immunology
Alu Elements - genetics
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - genetics
Alzheimer Disease - psychology
Alzheimer’s disease
Amyloid beta-Peptides - cerebrospinal fluid
Apolipoproteins E - genetics
DNA Methylation
DNA, Satellite - genetics
Epigenetics
Female
Humans
Long Interspersed Nucleotide Elements - genetics
Male
Middle Aged
Peripheral blood leukocytes
Phosphorylation
Protein Processing, Post-Translational
Psychiatry
Psychological Tests
Repetitive elements
tau Proteins - cerebrospinal fluid
Epigenetics
DNA methylation
Alzheimer’s disease
Peripheral blood leukocytes
Repetitive elements
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Summary:Research highlights ► DNA methylation is able to modify genome function and chromosomal stability. ► DNA methylation patterns is mainly determined by repetitive elements methylation. ► LINE-1 was increased in AD patients compared with healthy volunteers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.01.017