Neuroprotector effect of stem cells from human exfoliated deciduous teeth transplanted after traumatic spinal cord injury involves inhibition of early neuronal apoptosis

Highlights • SHED transplantation one hour after SCI inhibits early neuronal apoptosis. • SHED promoted the motor neuron preservation in the ventral horn of spinal cord. • SHED reduces astrocyte hyperplasia after spinal cord contusion. • SHED inhibits T cells entrance into the parenchyma of injured...

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Published inBrain research Vol. 1663; pp. 95 - 105
Main Authors Nicola, Fabrício do Couto, Marques, Marília Rossato, Odorcyk, Felipe, Arcego, Danusa Mar, Petenuzzo, Letícia, Aristimunha, Dirceu, Vizuete, Adriana, Sanches, Eduardo Farias, Pereira, Daniela Pavulack, Maurmann, Natasha, Dalmaz, Carla, Pranke, Patricia, Netto, Carlos A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.05.2017
Subjects
Adult Stem Cells - pathology
Adult Stem Cells - transplantation
Animals
Apoptosis
Astrocytes - pathology
Cell death
Cell Survival
Cells, Cultured
Dental pulp stem cell
Humans
Male
Mesenchymal stem cell
Neurology
Neurons - physiology
Neuroprotection
Neuroprotective Agents - metabolism
Rats
Rats, Wistar
Recovery of Function - physiology
Spinal Cord - pathology
Spinal Cord Injuries - physiopathology
Spinal Cord Injuries - therapy
Stem Cells - pathology
Tissue protection
Tooth, Deciduous - metabolism
Tooth, Deciduous - transplantation
Mesenchymal stem cell
Tissue protection
Neuroprotection
Dental pulp stem cell
Cell death
Apoptosis
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Summary:Highlights • SHED transplantation one hour after SCI inhibits early neuronal apoptosis. • SHED promoted the motor neuron preservation in the ventral horn of spinal cord. • SHED reduces astrocyte hyperplasia after spinal cord contusion. • SHED inhibits T cells entrance into the parenchyma of injured spinal cord.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.03.015