Hydrogen: A Novel Option in Human Disease Treatment

H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmon...

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Published inOxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 17
Main Authors Zhao, Mingyi, Shen, Jie, Zhuang, Quan, Zhu, Ping, He, Qingnan, Dong, Yinmiao, Yang, Mengling, Zhang, Xueyan
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
Hindawi Limited
Subjects
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Betacoronavirus
Cell adhesion & migration
Chemical elements
Chemokines
Coronavirus Infections - therapy
Coronaviruses
COVID-19
Cytokines
Endoplasmic reticulum
Energy Metabolism - drug effects
Granulocytes
Humans
Hydrogen
Hydrogen - administration & dosage
Hydrogen - pharmacology
Inflammation
Ischemia
Kinases
Mammals
Metabolism
Mitochondria
Oxidative stress
Oxidative Stress - drug effects
Pandemics
Pneumonia
Pneumonia, Viral - therapy
Protective Agents - pharmacology
Proteins
Regulation
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Tumor necrosis factor-TNF
China
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Summary:H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Luciano Saso
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/8384742