Portrait of Candida Species Biofilm Regulatory Network Genes

Most cases of candidiasis have been attributed to Candida albicans , but Candida glabrata , Candida parapsilosis and Candida tropicalis , designated as non- C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem ass...

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Published inTrends in microbiology (Regular ed.) Vol. 25; no. 1; pp. 62 - 75
Main Authors Araújo, Daniela, Henriques, Mariana, Silva, Sónia
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.2017
Elsevier Science Ltd
Subjects
biofilm
Biofilms
Biofilms - growth & development
Candida
Candida - growth & development
Candida - pathogenicity
Candida albicans
Candida glabrata
Candida parapsilosis
Candida species
Candida tropicalis
Candidiasis
Candidiasis - microbiology
Candidiasis - pathology
Cell Adhesion - physiology
Colonization
Dispersal
Fungal infections
Genes
Humans
Hyphae - genetics
Hyphae - growth & development
Internal Medicine
Pathogens
regulatory genes
Studies
regulatory genes
Candida species
biofilm
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Summary:Most cases of candidiasis have been attributed to Candida albicans , but Candida glabrata , Candida parapsilosis and Candida tropicalis , designated as non- C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem associated with significant rates of mortality. Biofilms have distinct developmental phases, including adhesion/colonisation, maturation and dispersal, controlled by complex regulatory networks. This review discusses recent advances regarding Candida species biofilm regulatory network genes, which are key components for candidiasis.
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ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2016.09.004