Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older

• Published in: Journal of diabetes research Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Lv, Zhao-hui, Chen, Kang, Wang, Haibing, Yang, Shanshan, Zhao, Kun, Mu, Yi-Ming
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; Hindawi Limited; Wiley
• Subjects: Adult; Aged; Alcohol; Asians; Blood pressure; Body mass index; Cardiovascular disease; China; Cholesterol; Cross-Sectional Studies; Diabetes; Education; Family medical history; Female; Genotype & phenotype; Glucose; Glucose Intolerance; Glucose Tolerance Test; Health risk assessment; Heart attacks; Humans; Hypertension; Hypertriglyceridemic Waist - complications; Hypertriglyceridemic Waist - ethnology; Laboratories; Lipids - chemistry; Lipoproteins; Male; Metabolism; Middle Aged; Odds Ratio; Phenotype; Prediabetic State - complications; Prediabetic State - ethnology; Prevalence; Questionnaires; Regression Analysis; Risk Factors; Smoking; Triglycerides; Triglycerides - blood; Variance analysis; Waist Circumference; Womens health; China
• ISSN: 2314-6745; 2314-6753
• DOI: 10.1155/2018/1031939

Objective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results. Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.48–1.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype with impaired glucose tolerance (IGT) (OR: 1.83; 95% CI: 1.57–2.13), but not with impaired fasting glucose (IFG) (OR: 0.87; 95% CI: 0.65–1.17). Only women with the HTGW phenotype are significantly associated with the combined IFG and IGT (OR: 1.83; 95% CI: 1.28–2.62). Conclusions. The HTGW phenotype was a useful risk indicator and a practical screening tool to benefit in the early diagnosis and intervention for prediabetes, particularly for IGT and the combined IFG and IGT.