NLRP3 Inflammasome and Inflammatory Diseases

Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation a...

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Published inOxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 11
Main Authors Li, Li, Qian, Weikun, Qin, Tao, Wu, Shuai, Zhang, Wunai, Xiao, Ying, Zhang, Simei, Wang, Zheng, Yue, Yangyang
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
Hindawi Limited
Subjects
Atherosclerosis
Bone marrow
Cytokines
Infections
Inflammation
Inflammatory diseases
Mitochondria
Mitochondrial DNA
Pathogens
Proteins
Researchers
Review
Rheumatism
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Summary:Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Guest Editor: Marco Cordani
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/4063562