Characterization of sonochemically prepared human serum albumin nanocapsules using different plant oils as core component for targeted drug delivery

• Published in: Ultrasonics sonochemistry Vol. 76; p. 105617
• Main Authors: Skoll, Katharina, Ritschka, Matthias, Fuchs, Stefanie, Wirth, Michael, Gabor, Franz
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2021; Elsevier
• Subjects: Drug Carriers - chemistry; Human serum albumin; Humans; Nanocapsules - chemistry; Original; Particle Size; Plant Oils - chemistry; Proteinaceous nanocapsules; Serum Albumin, Human - chemistry; Sonochemical preparation; Targeted drug delivery; Ultrasonic Waves; Wheat Germ Agglutinins - chemistry; Proteinaceous nanocapsules; Human serum albumin; Targeted drug delivery; Sonochemical preparation
• ISSN: 1350-4177; 1873-2828; 1873-2828
• DOI: 10.1016/j.ultsonch.2021.105617

•Proteinaceous nanocapsules (NCs) with a narrow size distribution could be prepared.•NCs with biocompatible oil cores could be produced avoiding toxic cross-linkers.•WGA as a targeter molecule was embedded in the proteinaceous particle shell.•WGA-modified NCs could be used for tumor targeting. The focus of this study is the preparation of proteinaceous human serum albumin (HSA) nanocapsules with biocompatible plant oil cores avoiding toxic cross-linker and noxious non-aqueous liquids. The sonochemical preparation of HSA capsules with different plant oils yields particles with narrow size distribution forming suspensions stable for at least 14 days and enabling long-term storage by freezing. Furthermore, wheat germ agglutinin (WGA) as a targeting molecule was successfully embedded into the proteinaceous particle shell at a molar ratio of 7:1 (HSA/WGA). As urothelial cell binding studies revealed up to 55% higher cell binding potential of WGA-grafted particles than those without a targeter, targeted protein nanocapsules represent the first step towards new and innovative formulations.