A glial blueprint for gliomagenesis

• Published in: Nature reviews. Neuroscience Vol. 19; no. 7; pp. 393 - 403
• Main Authors: Laug, Dylan, Glasgow, Stacey M., Deneen, Benjamin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2018; Nature Publishing Group
• Subjects: 631/136/532/71; 631/378/2571/219; 631/378/2596/1308; Animal Genetics and Genomics; Animals; Astrocytes - physiology; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain cancer; Brain Neoplasms - etiology; Brain Neoplasms - physiopathology; Brain tumors; Cancer; Carcinogenesis; Care and treatment; Cell Differentiation; Gene mutation; Glial cells; Glioma; Glioma - etiology; Glioma - physiopathology; Glioma cells; Gliomas; Humans; Medical schools; Neural Stem Cells - physiology; Neurobiology; Neuronal-glial interactions; Neurosciences; Novels; Oligodendroglia - physiology; Review Article; Stem cells; Therapeutics; Tumorigenesis; Tumors

Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. We explore glioma tu...