A glial blueprint for gliomagenesis

Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. We explore glioma tu...

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Bibliographic Details
Published inNature reviews. Neuroscience Vol. 19; no. 7; pp. 393 - 403
Main Authors Laug, Dylan, Glasgow, Stacey M., Deneen, Benjamin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2018
Nature Publishing Group
Subjects
631/136/532/71
631/378/2571/219
631/378/2596/1308
Animal Genetics and Genomics
Animals
Astrocytes - physiology
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain cancer
Brain Neoplasms - etiology
Brain Neoplasms - physiopathology
Brain tumors
Cancer
Carcinogenesis
Care and treatment
Cell Differentiation
Gene mutation
Glial cells
Glioma
Glioma - etiology
Glioma - physiopathology
Glioma cells
Gliomas
Humans
Medical schools
Neural Stem Cells - physiology
Neurobiology
Neuronal-glial interactions
Neurosciences
Novels
Oligodendroglia - physiology
Review Article
Stem cells
Therapeutics
Tumorigenesis
Tumors
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Summary:Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it produces the vast cellular constituency associated with frank glioma remains poorly defined. We explore glioma tumorigenesis through the lens of glial development, starting with the neurogenic–gliogenic switch and progressing through oligodendrocyte and astrocyte differentiation. Beginning with the factors that influence normal glial linage progression and diversity, a pattern emerges that has useful parallels in the development of glioma and may ultimately provide targetable pathways for much-needed new therapeutics. Gliomas represent the most deadly of human brain tumours; however, little progress has been made towards their successful treatment. In this Review, Deneen and colleagues discuss how glioma tumorigenesis resembles glial development and how this may inform novel therapies.
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ISSN:1471-003X
1471-0048
1469-3178
DOI:10.1038/s41583-018-0014-3