Multicenter study of the Artisan phakic intraocular lens

• Published in: Journal of cataract and refractive surgery Vol. 26; no. 8; pp. 1163 - 1171
• Main Authors: Budo, Camille, Hessloehl, Jean C, Izak, Milan, Luyten, Gregorius P.M, Menezo, Jose L, Sener, Bozkurt A, Tassignon, Marie José, Termote, Herve, Worst, Jan G.F
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2000; Elsevier Science
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Cell Count; Endothelium, Corneal - pathology; Europe; Female; Humans; Lens Implantation, Intraocular; Lenses, Intraocular; Male; Medical sciences; Middle Aged; Myopia - surgery; Prognosis; Prosthesis Design; Refraction, Ocular; Safety; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Visual Acuity; Europe; Human; Vision disorder; Multicenter study; Myopia; Implantation; Eye; Prospective; Eye disease; Treatment; Surgery; Refractive error; Anterior chamber; Technique; Intraocular lens
• ISSN: 0886-3350; 1873-4502
• DOI: 10.1016/S0886-3350(00)00545-9

To assess the Artisan intraocular lens to correct myopia in phakic eyes. European multicenter study sponsored by Ophtec BV, Groningen, The Netherlands. In this prospective multicenter clinical study, the Artisan lens was implanted in 518 eyes between September 1991 and October 1999. The power of the lenses ranged from −5.0 to −20.0 diopters (D). Follow-up examinations were performed at 6 months and 1, 2, and 3 years. Follow-up ranged from 6 months (n = 454) to 3 years (n = 249). The preoperative uncorrected visual acuity (UCVA) was not recorded but was estimated to be worse than 0.1. The preoperative mean best spectacle-corrected visual acuity (BSCVA) was 0.67 ± 0.26 (SD). Endothelial cell counts were done at 6 months and 1, 2, and 3 years in a subgroup of 129 eyes. A UCVA of 20/40 or better was observed in 76.8% of eyes regardless of the postoperative goal. A BSCVA of 20/40 or better was observed in 93.9% of eyes and remained stable throughout the follow-up. Of the eyes with extremely high myopia (>−15.0 D), 63.3% gained 2 or more lines of BSCVA; of those with moderate myopia (−5.0 to −10.0 D), 23.5% gained 2 or more lines. The mean endothelial cell density change was 4.8% at 6 months, 2.4% at 1 year, 1.7% at 2 years, and 0.7% at 3 years. The incidence of persistent adverse events at 3 years was relatively low. Secondary surgical interventions included repositioning of the lens because of poor initial placement and lens exchange because of preoperative power calculation errors. Glare and halo effects during night driving were noted and were related to large pupils in young patients. The Artisan lens is a safe, stable, efficacious, and predictable method to correct −5.0 to −20.0 D of myopia. This study suggests that the corneal endothelial cell loss is stabilized to the physiologically normal level after 3 years.