Material-Sparing and Expedited Development of a Tablet Formulation of Carbamazepine Glutaric Acid Cocrystal– a QbD Approach

• Published in: Pharmaceutical Research Vol. 37; no. 8; p. 153
• Main Authors: Yamashita, Hiroyuki, Sun, Changquan Calvin
• Format: Journal Article
• Language: English
• Published: New York Springer Science and Business Media LLC 01.08.2020; Springer US; Springer; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Carbamazepine; Carbamazepine - chemistry; Carbamazepine - pharmacology; Cellulose; Cellulose - chemistry; Crystallization; Dissolution; Drug Compounding; Excipients; Excipients - chemistry; Glutarates; Glutarates - chemistry; Glutarates - pharmacology; Medical Law; Pharmacology/Toxicology; Pharmacy; Phase Transition; Powders; Research Paper; Silicon Dioxide; Silicon Dioxide - chemistry; Solubility; Tablets; Tablets - chemistry; quality by design; tablet; material-sparing; cocrystal; formulation development; manufacturability
• ISSN: 0724-8741; 1573-904X; 1573-904X
• DOI: 10.1007/s11095-020-02855-3

Purpose To efficiently develop a tablet formulation of carbamazepine using a soluble cocrystal with excess coformer to maintain phase stability during dissolution. Methods The carbamazepine – glutaric acid cocrystal (CBZ-GLA, 1:1) and excess glutaric acid (GLA) were mixed with suitable tablet excipients, which were selected to address powder flowability and tabletability deficiencies specifically. Tablet friability and dissolution profiles were evaluated to guide formulation optimization. Dry granules were prepared by milling simulated ribbons. Results A binary blend of CBZ-GLA and GLA had poor flowability and marginal tabletability. Therefore, silica coated Avicel PH-102 (sMCC) was applied as a binder to improve the flow property and tabletability. A formulation consisting of sMCC, CBZ-GLA, and GLA exhibited good manufacturability but did not show improved dissolution because of rapid precipitation of CBZ dihydrate when CBZ-GLA came in contact with water. Dry granulation of CBZ-GLA and GLA dramatically improved dissolution profile due to the intimate contact between CBZ-GLA and GLA. Such cocrystal - coformer granules also led to much improved tablet manufacturability and dissolution. Conclusion The successful tablet development of CBZ-GLA, using < 3 g of the cocrystal in <3 weeks, demonstrates an efficient workflow for tablet formulation development based on material-sparing and predictive powder characterization techniques. This workflow is useful for early tablet development using enabling solid form, such as cocrystal, when only a small amount of material is available.