Antigenic and Genetic Properties of Viruses Linked to Hemorrhagic Fever with Renal Syndrome

• Published in: Science (American Association for the Advancement of Science) Vol. 227; no. 4690; pp. 1041 - 1044
• Main Authors: Schmaljohn, C. S., Hasty, S. E., Dalrymple, J. M., LeDuc, J. W., Lee, H. W., C.-H. Von Bonsdorff, Brummer-Korvenkontio, M., Vaheri, A., Tsai, T. F., Regnery, H. L., Goldgaber, D., Lee, P. W.
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 01.03.1985; American Association for the Advancement of Science
• Subjects: Animals; Antigens, Viral - immunology; Arvicolinae; Base Sequence; Biological and medical sciences; Bunyaviridae; Bunyaviridae - genetics; Cell culture techniques; Genomes; Hantavirus - genetics; Hantavirus - immunology; Hemorrhagic fever; Hemorrhagic fever with renal syndrome; Hemorrhagic Fever with Renal Syndrome - genetics; Hemorrhagic Fever with Renal Syndrome - immunology; Hemorrhagic Fever with Renal Syndrome - microbiology; Hemorrhagic fevers; Human viral diseases; Humans; Infections; Infectious diseases; Korea; Medical sciences; Mice; Muridae; Neutralization Tests; Observations; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA; RNA Viruses - immunology; Rodents; United States; Viral diseases; Viral research; Virus research; Viruses; United States; Korea; Genetics; Immunological investigation; Korean hemorrhagic fever; Viral disease; Arbovirus disease
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2858126

Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.