Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides
Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-mala...
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Published in | Acta pharmacologica Sinica Vol. 35; no. 3; pp. 316 - 330 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.03.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles. |
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Bibliography: | natural product; resorcinolic macrolide; fungal metabolite; bioactivity; anti-tumor; anti-bacteria; anti-malaria; biosynthesis Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles. 31-1347/R ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 These authors contributed equally to this work. |
ISSN: | 1671-4083 1745-7254 |
DOI: | 10.1038/aps.2013.155 |