Major Glycoprotein Antigens that Induce Antibodies in AIDS Patients are Encoded by HTLV-III

• Published in: Science (American Association for the Advancement of Science) Vol. 228; no. 4703; pp. 1091 - 1094
• Main Authors: Allan, J. S., Coligan, J. E., Barin, F., McLane, M. F., Sodroski, J. G., Rosen, C. A., Haseltine, W. A., Lee, T. H., Essex, M.
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 31.05.1985; American Association for the Advancement of Science
• Subjects: Acquired Immunodeficiency Syndrome - immunology; AIDS; AIDS (Disease); AIDS research; AIDS/HIV; Amino Acid Sequence; Antibodies; Antibodies, Viral - immunology; Antigens, Viral - genetics; Antigens, Viral - immunology; Base Sequence; Biological and medical sciences; Cancer; Cancer research; Cellular immunity; Deltaretrovirus - immunology; Genes, Viral; Glycoproteins; Glycoproteins - genetics; Glycoproteins - immunology; HIV; HTLV viruses; Human T lymphotropic virus 1; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Medical sciences; Molecular Weight; Nucleotide sequences; Oncology, Experimental; Open reading frames; Proteins; T cells; Tunicamycin - pharmacology; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Viruses; Human; Immunopathology; Genome organization; Skin disease; Antibody; Gene product; Inheritance; Retroviridae; AIDS; Primary structure; Glycoproteins; Hemopathy; Host virus relation; Infection; Virus; Antigen; Viral disease; Virus envelope; Venereal disease
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2986290

Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3$^{\prime}$ end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.