The Otoprotective Effect of Ear Cryotherapy: Systematic Review and Future Perspectives

This systematic review investigates ear cooling and cryotherapy in the prevention and treatment of inner ear damage and disease, within the context of animal models and clinical studies. A literature search was carried out in the databases Pubmed and Cochrane Library. Ten studies were identified con...

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Bibliographic Details
Published inAudiology research (Pavia, Italy) Vol. 12; no. 4; pp. 377 - 387
Main Authors Péus, Dominik, Sellathurai, Shaumiya, Newcomb, Nicolas, Tschopp, Kurt, Radeloff, Andreas
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.07.2022
MDPI
Subjects
Cooling
Cryotherapy
Hearing loss
Hypothermia
inner ear
Irrigation
Otolaryngology
otoprotection
Review
Steroids
Tinnitus
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Summary:This systematic review investigates ear cooling and cryotherapy in the prevention and treatment of inner ear damage and disease, within the context of animal models and clinical studies. A literature search was carried out in the databases Pubmed and Cochrane Library. Ten studies were identified concerning the otoprotective properties of cryotherapy. Nine of these were rodent in vivo studies (mice, rats, gerbils, guinea pigs). One study involved human subjects and investigated cryotherapy in idiopathic sensorineural hearing loss. The studies were heterogeneous in their goals, methods, and the models used. Disorder models included ischemia and noise damage, ototoxicity (cisplatin and aminoglycoside), and CI-electrode insertion. All ten studies demonstrated significant cryotherapeutic otoprotection for their respective endpoints. No study revealed or expressly investigated otodestructive effects. While limited in number, all of the studies within the scope of the review demonstrated some degree of cryotherapeutic, otoprotective effect. These promising results support the conducting of further work to explore and refine the clinical applicability and impact of cryotherpeutics in otolaryngology.
ISSN:2039-4349
2039-4330
2039-4349
DOI:10.3390/audiolres12040038