Estrogenic regulation of Kiss1 mRNA variants in Hatano rats

• Published in: General and comparative endocrinology Vol. 181; no. 15; pp. 246 - 253
• Main Authors: Horii, Yasuyuki, Dalpatadu, Sandun L, Soga, Tomoko, Ohta, Ryo, Watanabe, Gen, Taya, Kazuyoshi, Parhar, Ishwar S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2013
• Subjects: Animals; Brain - drug effects; Brain - metabolism; Endocrinology & Metabolism; Estradiol - pharmacology; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; estrogen receptors; Estrous cycle; Estrous Cycle - drug effects; Estrous Cycle - genetics; Female; females; gene expression; Gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - metabolism; Kisspeptin; Kisspeptins - genetics; Luteinizing hormone; Luteinizing Hormone - metabolism; messenger RNA; neurons; ovariectomy; Polymerase Chain Reaction; preoptic area; Protein Binding - drug effects; Protein Binding - genetics; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reproduction; Reproduction - drug effects; Reproduction - genetics; secretion; strain differences; Kisspeptin; Luteinizing hormone; Reproduction; Gonadotropin-releasing hormone; Estrous cycle
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2012.10.004

Highlights ► Two Kiss1 mRNA variants, Kiss1 V1 and Kiss1 V2, were isolated in rats. ► The Kiss1 V2 expression was higher than Kiss1 V1 in the AVPV of HAA but not LAA rats. ► E2 increased Kiss1 V1 and Kiss1 V2 expression in the AVPV of HAA rats. ► E2 had no effect on Kiss1 V1 or Kiss1 V2 expression in the AVPV of LAA rats.