Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines

• Published in: Current opinion in immunology Vol. 23; no. 5; pp. 591 - 597
• Main Authors: Barker, Brianne R, Taxman, Debra J, Ting, Jenny P-Y
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2011
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Signal Transducing - metabolism; Allergy and Immunology; Animals; Caspase 1 - genetics; Caspase 1 - immunology; Caspase 1 - metabolism; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - immunology; DEAD-box RNA Helicases - metabolism; Gene Expression Regulation - immunology; Gene Regulatory Networks - immunology; Humans; Immunity, Innate; Inflammasomes - genetics; Inflammasomes - immunology; Inflammasomes - metabolism; Inflammation - genetics; Inflammation - immunology; Inflammation - metabolism; Interleukin-18 - genetics; Interleukin-18 - immunology; Interleukin-18 - metabolism; Interleukin-1beta - genetics; Interleukin-1beta - immunology; Interleukin-1beta - metabolism; Macrophages - immunology; Macrophages - metabolism; Mice; NF-kappa B - genetics; NF-kappa B - immunology; NF-kappa B - metabolism; Signal Transduction - immunology
• ISSN: 0952-7915; 1879-0372
• DOI: 10.1016/j.coi.2011.07.005

Highlights ► The IL-1β/IL-18-processing inflammasome is composed of an NLR sensor, Aim2 or RIG-I; the adaptor ASC/Pycard; and caspase-1. ► Many inflammasome components have roles in the transcriptional induction of non-inflammasome cytokines. ► Caspase-1 also is proposed to have a role in the processing of growth factors through the unconventional secretory pathway. ► Other cytokines may influence the inflammasome transcriptionally or via direct interaction with inflammasome components. ► This cross-regulation may lead to increased abilities for the cell to respond appropriately to diverse pathogen threats.