Development of Therapeutic Antibodies and Modulating the Characteristics of Therapeutic Antibodies to Maximize the Therapeutic Efficacy

Monoclonal antibodies (mAb) have been used as therapeutic agents for various diseases, and immunoglobulin G (IgG) is mainly used among antibody isotypes due to its structural and functional properties. So far, regardless of the purpose of the therapeutic antibody, wildtype IgG has been mainly used,...

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Published inBiotechnology and bioprocess engineering Vol. 26; no. 3; pp. 295 - 311
Main Authors Kang, Seung Hyun, Lee, Chang-Han
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Biotechnology and Bioengineering 01.06.2021
Springer Nature B.V
한국생물공학회
Subjects
Antibodies
bioprocessing
Biotechnology
Chemical compounds
Chemistry
Chemistry and Materials Science
IgG antibody
Immunoglobulin G
Industrial and Production Engineering
Invited Review Paper
Isotypes
Monoclonal antibodies
Pharmacology
Structure-function relationships
therapeutics
생물공학
antibody engineering
therapeutic antibody
bispecific antibody
Fc engineering
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Summary:Monoclonal antibodies (mAb) have been used as therapeutic agents for various diseases, and immunoglobulin G (IgG) is mainly used among antibody isotypes due to its structural and functional properties. So far, regardless of the purpose of the therapeutic antibody, wildtype IgG has been mainly used, but recently, the engineered antibodies with various strategies according to the role of the therapeutic antibody have been used to maximize the therapeutic efficacy. In this review paper, first, the overall structural features and functional characteristics of antibody IgG, second, the old and new techniques for antibody discovery, and finally, several antibody engineering strategies for maximizing therapeutic efficacy according to the role of a therapeutic antibody will be introduced.
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ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-020-0181-8