Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece
Abstract Introduction Association studies of vitamin D receptor ( VDR ) polymorphisms and risk of type 1 diabetes (T1D) have produced inconsistent results in different populations, pointing to contribution of additional genetic variants and environmental factors. In this study we investigated the as...
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Published in | Clinical immunology (Orlando, Fla.) Vol. 133; no. 2; pp. 276 - 281 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
01.11.2009
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Abstract Introduction Association studies of vitamin D receptor ( VDR ) polymorphisms and risk of type 1 diabetes (T1D) have produced inconsistent results in different populations, pointing to contribution of additional genetic variants and environmental factors. In this study we investigated the association between four VDR polymorphisms and susceptibility to T1D in Crete, an island with homogenous population and considerably low incidence of T1D. Results and discussion We genotyped 100 patients with T1D and 96 controls for the Fok I (rs10735810), Bsm I (rs1544410), Apa I (rs7975232), and Taq I (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. In all 4 polymorphisms tested, distribution of VDR genotype frequencies differed significantly between patients and controls. Individuals with T1D presented less commonly with Fok I F allele ( p = 0.008; OR 0.52, 95% CI 0.32 to 0.85) and Bsm I B allele ( p = 0.042; OR 0.65, 95% CI 0.44 to 0.97) and more commonly with Apa I A allele ( p = 0.024; OR 1.61, 95% CI 1.07 to 2.41) and Taq I T allele ( p = 0.0001; OR 2.24, 95% CI 1.49 to 3.36). Conclusion Our findings derived from a homogenous southern European population with low incidence of T1D suggest that Fok I, Bsm I, Apa I, and Taq I polymorphisms of the VDR gene are associated with T1D prevalence. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1521-6616 1521-7035 |
DOI: | 10.1016/j.clim.2009.08.004 |