Positive Selection and Duplication of Bat TRIM Family Proteins

• Published in: Viruses Vol. 15; no. 4; p. 875
• Main Authors: Xie, Jiazheng, Tan, Bowen, Zhang, Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.03.2023; MDPI
• Subjects: Animals; antiviral immunity; Bats; Brief Report; Cell cycle; Cellular proteins; Chiroptera; Coronaviruses; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; DNA viruses; Evolutionary genetics; gene duplication; Genes; Genetic aspects; Genome; Genomes; Humans; Longevity; Phylogeny; Positive selection; Proteins; Severe acute respiratory syndrome coronavirus 2; Transcriptomics; TRIM; Tripartite Motif Proteins - genetics; Tumor suppression; Viruses; Viruses - genetics; China; positive selection; antiviral immunity; TRIM; gene duplication; Chiroptera
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v15040875

Bats have received increasing attention because of some unique biological features they possess. TRIM is a large family of proteins that participate in diverse cellular functions, such as antiviral immunity, DNA damage repair, tumor suppression, and aging. These functional areas appear to be highly consistent with the special characteristics of bats, such as tolerance to viruses and DNA damage generated in flight, low cancer incidence, and longevity. However, there is still a lack of systematic study of the TRIM family in bats. Here, we explored the TRIM family of bats using the genomes of 16 representative species. The results showed that the bat TRIM family contains 70 members, with 24 under positive selection and 7 duplicated. Additional transcriptomic analysis revealed the tissue-specific expressions of , , , , , and . Additionally, following interferon or viral stimulation, orthologs associated with antiviral immunity reported in humans were also upregulated in bat cells. The present study systematically analyzed the composition, evolution, and expression of bat genes. It may provide a theoretical basis for studies of bat TRIM in the fields of antiviral immunity, longevity, and tolerance to DNA damage.