The Mitochondrial Theory of Aging and Its Relationship to Reactive Oxygen Species Damage and Somatic mtDNA Mutations

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 102; no. 52; pp. 18769 - 18770
Main Authors Loeb, Lawrence A., Wallace, Douglas C., Martin, George M.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 27.12.2005
National Acad Sciences
Subjects
Adenosine Triphosphate - metabolism
Aging - physiology
Animals
Apoptosis
Bacteria
Cellular Senescence
Commentaries
DNA
DNA Damage
DNA Polymerase gamma
DNA, Mitochondrial - genetics
DNA-Directed DNA Polymerase - metabolism
Free Radicals
Genetic mutation
Genomes
Humans
Mice
Mitochondria
Mitochondria - pathology
Mitochondrial DNA
Models, Biological
Mutation
Phenotype
Proteins
Reactive Oxygen Species
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Conflict of interest statement: No conflicts declared.
Author contributions: L.A.L., D.C.W., and G.M.M. analyzed data and wrote the paper.
See companion article on page 17993 in issue 50 of volume 102.
To whom correspondence should be addressed. E-mail: laloeb@u.washington.edu.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0509776102