Circulating tumor cells: a window into cancer biology and metastasis

The presence of circulating tumor cells (CTCs) accompanies tumor invasion into the bloodstream. Detection, monitoring, and molecular analysis of these rare cancer cells shed into blood will provide a powerful and noninvasive approach for the detection of early disease, assessing prognosis and therap...

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Published inCurrent opinion in genetics & development Vol. 20; no. 1; pp. 96 - 99
Main Authors Maheswaran, Shyamala, Haber, Daniel A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2010
Subjects
Blood
Cell Separation - methods
Cyclophosphamide - analogs & derivatives
Drug Delivery Systems
Humans
Medical Education
Neoplasm Metastasis
Neoplastic Cells, Circulating - pathology
Neoplastic Stem Cells - pathology
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Summary:The presence of circulating tumor cells (CTCs) accompanies tumor invasion into the bloodstream. Detection, monitoring, and molecular analysis of these rare cancer cells shed into blood will provide a powerful and noninvasive approach for the detection of early disease, assessing prognosis and therapeutic response in established cancers, and targeting metastatic precursor cells. We review current and emerging technologies for CTC isolation, with a focus on capture efficiency, purity, and viability of CTCs, and their potential clinical applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2009.12.002