Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients

• Published in: Mediators of inflammation Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Giannopoulos, Krzysztof, Chodorowska, Grażyna, Kowal, Małgorzata, Michalak-Stoma, Anna, Purkot, Joanna, Raczkiewicz, Dorota, Zakrzewska, Ewelina, Bartosińska, Joanna, Krasowska, Dorota
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; Hindawi Limited; Wiley
• Subjects: Adult; Apoptosis; Archives & records; CD3 antigen; CD3 Complex - metabolism; CD4 antigen; CD4-Positive T-Lymphocytes - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell death; Dermatology; Disease; Female; Flow Cytometry; Humans; Immunological tolerance; Immunology; Immunoregulation; Inflammation; Inflammatory diseases; Ligands; Lymphocytes; Lymphocytes T; Male; Metastasis; Middle Aged; Pathogens; Patients; PD-1 protein; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Psoriasis; Psoriasis - metabolism; Skin; T cell receptors; Poland
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2017/5385102

Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.