Drug interactions among older adults followed up in a comprehensive medication management service at Primary Care

• Published in: Einstein (São Paulo, Brazil) Vol. 17; no. 4; p. eAO4725
• Main Authors: Santos, Tayane Oliveira Dos, Nascimento, Mariana Martins Gonzaga do, Nascimento, Yone Almeida, Oliveira, Grazielli Cristina Batista de, Martins, Ursula Carolina de Morais, Silva, Danielle Fernandes da, Oliveira, Djenane Ramalho de
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein 22.08.2019
• Subjects: Conduta do tratamento medicamentoso; Farmacêuticos; Idoso; Interações medicamentosas; Lista de medicamentos potencialmente inapropriados; MEDICINE, GENERAL & INTERNAL; Original; Farmacêuticos; Conduta do tratamento medicamentoso; Idoso; Drug interactions; Medication therapy management; Interações medicamentosas; Potentially inappropriate medication list; Aged; Pharmacists; Lista de medicamentos potencialmente inapropriados
• ISSN: 1679-4508; 2317-6385; 2317-6385
• DOI: 10.31744/einstein_journal/2019AO4725

To estimate the prevalence of drug interactions and associated factors among older adults followed up in a Comprehensive Medication Management Service at Primary Care. Firstly, the Beers criteria 2015 was used to define drug interactions; later, drug interactions proposed by Dumbreck for patients with diabetes, depression, and heart failure were evaluated. The associated factors were assessed by univariate (Pearson's χ2) and multivariate analyses (logistic regression). The significance level of 5% was set for all analyses. The mean age of the studied population was 70.2±7.8 years; 52.2% were between 60 and 69 years, and 61.3% were female. Among the older adults, 94.5% used two or more drugs (condition for the occurrence of drug-drug interaction). The prevalence of drug interaction according to the Beers criteria was 4.9%. After multivariate analysis, diseases of the central nervous system, arrhythmia, number of medications, and female sex were positively associated with drug interaction. The prevalence of drug interaction according to Dumbreck was 27.2%. After multivariate analysis, the number of medications, the presence of heart failure, and Charlson comorbidity index greater than 1 were conditions positively associated with drug interactions. The holistic and individualized approach used in comprehensive medication management services for older patients is important, considering the prevalence of drug interactions and the need to minimize adverse events.