Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes

An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 27; no. 16; p. 5195
Main Authors Philippova, Anna N, Vorobyeva, Daria V, Gribanov, Pavel S, Godovikov, Ivan A, Osipov, Sergey N
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2022
MDPI
Subjects
Amination
Amines
Amino acids
Antiviral agents
azepines
Cancer
Carboxylates
Catalysis
Chromatography
cyclic amino acids
cyclization
Kinases
Mass spectrometry
Scientific imaging
Germany
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Summary:An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27165195