Determination of transcription factor binding

To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrog...

Full description

Saved in:
Bibliographic Details
Published inNature genetics Vol. 43; no. 1; pp. 11 - 12
Main Authors Ruan, Yijun, Cheung, Edwin
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2011
Nature Publishing Group
Subjects
631/208/200
631/45/612/822
631/67/1059/2326
692/699/67/1347
Agriculture
Animal Genetics and Genomics
Animals
Binding Sites
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cancer cells
Cancer Research
DNA-ligand interactions
Estrogen
Estrogen Receptor alpha - chemistry
Estrogen Receptor alpha - metabolism
Female
Gene expression
Gene Function
Genetic aspects
Hepatocyte Nuclear Factor 3-alpha - chemistry
Hepatocyte Nuclear Factor 3-alpha - genetics
Hepatocyte Nuclear Factor 3-alpha - metabolism
Human Genetics
Humans
news-and-views
Physiological aspects
Proteins
Receptors
Transcription factors
Singapore
Online AccessGet full text

Cover

More Information
Summary:To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrogen receptor a in breast cancer cells and in other cell types.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
ObjectType-Commentary-2
content type line 66
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1061-4036
1546-1718
DOI:10.1038/ng0111-11