Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 techn...

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Bibliographic Details
Published inCell Vol. 165; no. 6; pp. 1319 - 1322
Main Authors Popp, Maximilian W., Maquat, Lynne E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 02.06.2016
Subjects
CRISPR-Cas Systems
Gene Targeting
Genetic Engineering
Genome
Humans
Nonsense Mediated mRNA Decay
Precision Medicine
RNA, Messenger
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Summary:Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments. Understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and can also inform disease diagnostics and treatments.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.05.053