Occupational infection due to Brucella abortus S19 among workers involved in vaccine production in Argentina

The pathological consequences of exposure to the vaccine strain Brucella abortus S19 were evaluated in 30 employees from vaccine-manufacturing plants. Active brucellosis was diagnosed in 21 subjects, of whom only five recalled an accidental exposure. Clinical manifestations were mild, and only one p...

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Bibliographic Details
Published inClinical microbiology and infection Vol. 14; no. 8; pp. 805 - 807
Main Authors Wallach, J.C., Ferrero, M.C., Victoria Delpino, M., Fossati, C.A., Baldi, P.C.
Format Journal Article
LanguageEnglish
Published Oxford, UK Elsevier Ltd 01.08.2008
Blackwell Publishing Ltd
Blackwell
Subjects
Adult
Antibodies, Bacterial - blood
Argentina - epidemiology
Bacterial diseases
Biological and medical sciences
Biosafety
Brucella abortus
Brucella abortus - immunology
Brucella abortus - isolation & purification
Brucella abortus S19 vaccine
Brucella Vaccine
Brucellosis - diagnosis
Brucellosis - epidemiology
Brucellosis - physiopathology
Drug Industry - methods
Female
Human bacterial diseases
human brucellosis
Humans
Infectious diseases
laboratory workers
Male
Medical Laboratory Personnel
Medical sciences
Middle Aged
Miscellaneous
Occupational Exposure
South America
Argentina
America
human brucellosis
Biosafety
occupational exposure
Brucella abortus S19 vaccine
laboratory workers
Human
Vaccine
Brucella abortus
Laboratory
Occupational exposure
Infection
Prevention
Immunoprophylaxis
Work safety
Brucellaceae
Bacteriosis
Bacteria
Brucellosis
Occupational medicine
Public health
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Summary:The pathological consequences of exposure to the vaccine strain Brucella abortus S19 were evaluated in 30 employees from vaccine-manufacturing plants. Active brucellosis was diagnosed in 21 subjects, of whom only five recalled an accidental exposure. Clinical manifestations were mild, and only one patient presented a complication. After antimicrobial therapy, initially symptomatic patients either experienced clinical remission or had mild persistent symptoms. This is the first study reporting infection by B. abortus S19 among workers from vaccine-manufacturing plants, which in many cases was acquired from unnoticed exposures. Measures to improve the safety of B. abortus S19 handling should be implemented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2008.02029.x