COVID‐19 associated pulmonary aspergillosis

• Published in: Mycoses Vol. 63; no. 6; pp. 528 - 534
• Main Authors: Koehler, Philipp, Cornely, Oliver A., Böttiger, Bernd W., Dusse, Fabian, Eichenauer, Dennis A., Fuchs, Frieder, Hallek, Michael, Jung, Norma, Klein, Florian, Persigehl, Thorsten, Rybniker, Jan, Kochanek, Matthias, Böll, Boris, Shimabukuro‐Vornhagen, Alexander
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.06.2020; John Wiley and Sons Inc
• Subjects: Aged; Antifungal Agents - therapeutic use; Aspergillosis; Aspergillus; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - virology; Coronavirus Infections - complications; Coronavirus Infections - diagnostic imaging; Coronaviruses; COVID-19; ECMO; Female; Germany; Hemorrhage - etiology; Hospitals, Teaching; Humans; ICU; Intensive Care Units; isavuconazole; Lung Diseases - etiology; Male; Mannans - analysis; Metapneumovirus - isolation & purification; Middle Aged; Nitriles - therapeutic use; Original; Pandemics; Paramyxoviridae Infections - etiology; Patients; Pneumonia, Viral - complications; Pneumonia, Viral - diagnostic imaging; Pulmonary Aspergillosis - complications; Pulmonary Aspergillosis - diagnostic imaging; Pyridines - therapeutic use; Respiratory distress syndrome; Respiratory Distress Syndrome - complications; Respiratory Distress Syndrome - diagnostic imaging; Retrospective Studies; SARS‐CoV‐2; Thorax - diagnostic imaging; Tomography, X-Ray Computed; Triazoles - therapeutic use; voriconazole; Voriconazole - therapeutic use; Germany; ECMO; Aspergillus; SARS-CoV-2; ICU; isavuconazole; voriconazole
• ISSN: 0933-7407; 1439-0507; 1439-0507
• DOI: 10.1111/myc.13096

Summary Objectives Patients with acute respiratory distress syndrome (ARDS) due to viral infection are at risk for secondary complications like invasive aspergillosis. Our study evaluates coronavirus disease 19 (COVID‐19) associated invasive aspergillosis at a single centre in Cologne, Germany. Methods A retrospective chart review of all patients with COVID‐19 associated ARDS admitted to the medical or surgical intensive care unit at the University Hospital of Cologne, Cologne, Germany. Results COVID‐19 associated invasive pulmonary aspergillosis was found in five of 19 consecutive critically ill patients with moderate to severe ARDS. Conclusion Clinicians caring for patients with ARDS due to COVID‐19 should consider invasive pulmonary aspergillosis and subject respiratory samples to comprehensive analysis to detect co‐infection.