Liver injury during highly pathogenic human coronavirus infections

The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019 novel coronavirus disease (COVID‐19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS‐CoV‐2 infection an international public health emergency. Lung lesions have been...

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Bibliographic Details
Published inLiver International Vol. 40; no. 5; pp. 998 - 1004
Main Authors Xu, Ling, Liu, Jia, Lu, Mengji, Yang, Dongliang, Zheng, Xin
Format Journal Article Web Resource
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.05.2020
John Wiley & Sons, Inc
John Wiley and Sons Inc
Subjects
Betacoronavirus
Coronaviridae
Coronavirus Infections - pathology
Coronavirus Infections - physiopathology
Coronaviruses
COVID-19
Damage
Disease Progression
Health risks
Humans
Infections
Injuries
Liver
Liver - pathology
Liver - virology
liver injury
MERS
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus
Pandemics
Pneumonia, Viral - pathology
Pneumonia, Viral - physiopathology
Public health
Respiratory diseases
Review
Reviews
SARS
SARS Virus
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral diseases
COVID-19
SARS
SARS-CoV-2
liver injury
MERS
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Summary:The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019 novel coronavirus disease (COVID‐19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS‐CoV‐2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS‐CoV‐2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus – severe acute respiratory syndrome coronavirus (SARS‐CoV) and the Middle East respiratory syndrome coronavirus (MERS‐CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS‐CoV, MERS‐CoV as well as SARS‐CoV‐2 infection were summarized, which may provide help for further studies on the liver injury of COVID‐19.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Ling Xu and Jia Liu contributed equally to this work.
Handling Editor: Luca Valenti
ISSN:1478-3223
1478-3231
1478-3231
DOI:10.1111/liv.14435