Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp

• Published in: FEMS microbiology letters Vol. 251; no. 1; pp. 53 - 58
• Main Authors: Lin, Xin, Huang, Yaojian, Fang, Meijuan, Wang, Jianfeng, Zheng, Zhonghui, Su, Wenjin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier B.V 01.10.2005; Blackwell Publishing Ltd; Blackwell; Oxford University Press
• Subjects: Action of physical and chemical agents; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial; Antimicrobial activity; Antimicrobial agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Ascomycota - chemistry; Ascomycota - isolation & purification; Benzofurans - chemistry; Benzofurans - isolation & purification; Benzofurans - pharmacology; Benzofurans - toxicity; Biological and medical sciences; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Bridged-Ring Compounds - pharmacology; Bridged-Ring Compounds - toxicity; Cell culture; Cell Line; Cell lines; China; Conservation areas; Cytotoxic; Cytotoxicity; Diaporthe; Diaporthe sp; Fundamental and applied biological sciences. Psychology; Fungi; Humans; Kandelia candel; KB Cells; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Lignicolous fungi; Marine; Mass Spectrometry; Metabolites; Microbial Sensitivity Tests; Microbiology; Molecular Structure; Mycology; Nature conservation; Pyrones - chemistry; Pyrones - isolation & purification; Pyrones - pharmacology; Pyrones - toxicity; Water Microbiology; China People's Rep., Fujian Prov; Antimicrobial; Marine; Metabolites; Cytotoxic; Lignicolous fungi; Diaporthe sp; sp; Metabolite; Chemical structure; Cytotoxicity; Antimicrobial agent; Diaporthe; Fungi; Marine environment; Ascomycetes; Mass spectrometry; Thallophyta
• ISSN: 0378-1097; 1574-6968
• DOI: 10.1016/j.femsle.2005.07.025

A new compound ( 1), named diaporthelactone, together with two known compounds ( 2 and 3) were isolated from the culture of Diaporthe sp., a marine fungus growing in the submerged rotten leaves of Kandelia candel in the mangrove nature conservation areas of Fugong, Fujian Province of China. The new compound was elucidated to be 1,3-dihydro-4-methoxy-7-methyl-3-oxo-5-isobenzofuran-carboxyaldehyde ( 1), which showed cytotoxic activity against KB and Raji cell lines (IC 50 6.25 and 5.51 μg mL −1, respectively). Two known compounds, 7-methoxy-4,6-dimethyl-3 H-isobenzofuran-1-one ( 2) and mycoepoxydiene ( 3), were also demonstrated to exhibit cytotoxic activities for the first time. All three compounds were assessed for antimicrobial activity.