Polycyclic aromatic hydrocarbon distribution in serum of Saudi children using HPLC-FLD: marker elevations in children with asthma

• Published in: Environmental science and pollution research international Vol. 21; no. 20; pp. 12085 - 12090
• Main Authors: Al-Daghri, Nasser M, Alokail, Majed S, Abd-Alrahman, Sherif H, Draz, Hossam M
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.10.2014; Springer Berlin Heidelberg; Springer Nature B.V
• Subjects: Abdomen; Adolescent; Aluminum; Anthracene; anthracenes; Aquatic Pollution; Asthma; Asthma - blood; Atmospheric Protection/Air Quality Control/Air Pollution; Benzo(a)pyrene; Bioaccumulation; Biomarkers; Biomarkers - blood; Biomass; blood serum; Body mass index; Carcinogens; Case-Control Studies; Child; Child, Preschool; Children; Chromatography, High Pressure Liquid - methods; Chrysene; Developing countries; Diesel engines; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Fluoranthene; Fluorene; Fluorescence; Food; Food plants; Humans; Indoor air quality; Laboratory animals; LDCs; Liquid chromatography; monitoring; Mortality; Naphthalene; Outdoor air quality; people; Phenanthrene; Pollutants; Pollution; Pollution abatement; Polyallylamine hydrochloride; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - blood; Pyrene; Research Article; Respiration; Saudi Arabia; Serum levels; Serums; Signal to noise ratio; Waste Water Technology; Water Management; Water Pollution Control; Saudi Arabia; Riyadh Saudi Arabia; Egypt; Saudi Arabia, Riyadh; PAHs; Serum; Children; Environmental pollution; HPLC
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-014-3108-0

Diesel exhaust consists of a complex mixture of chemicals which contain known genotoxicants, one of which is polycyclic aromatic hydrocarbons (PAHs) which may be associated with adverse respiratory health outcomes. This study aimed to evaluate the distribution patterns of PAHs (anthracene, naphthalene, fluorene, phenanthrene, cyclopentaphenanthrene, pyrene, fluoranthene, benzanthracene, chrysene, benzo(e)pyrene, benzoacephenanthrylene, and benzo(a)pyrene) in serum collected from asthmatic and healthy control children. PAH serum levels were measured in samples collected from children who lived in 11 different locations in/round Riyadh, Saudi Arabia (Al-yarmouk, Usaibi, Sultana Al-kadema, Omrrojam, Kof, Janoob Dawdmi, Guberah, Arabbuah, Al-mozahemyah, Iskan Al-mazzer, and Al-gharabi) during the period 2010–2011. Our results showed that the highest total mean concentrations of PAH were found in serum samples collected from people who lived in Sultana Aljadhida, Almozahemyah, Guberah, and Omrrojam and were 663.9, 486.17, 412.18, and 258.6 ng ml⁻¹, respectively. The most prevalent PAHs in serum samples were naphthalene, bezanthracene, benzoacephenanthrylene, phenanthrene, chrysene, and benzo(a)pyrene with a frequency that ranged from 54.5 to 90.9 % positive samples. A close monitoring of PAH pollution is strongly recommended, especially in food and plant samples, because of their high bioaccumulation capacity.