Whole-exome and whole-transcriptome sequencing of canine mammary gland tumors

• Published in: Scientific data Vol. 6; no. 1; pp. 147 - 7
• Main Authors: Kim, Ka-Kyung, Seung, Byung-Joon, Kim, Dohyun, Park, Hee-Myung, Lee, Sejoon, Song, Doo-Won, Lee, Gunho, Cheong, Jae-Ho, Nam, Hojung, Sur, Jung-Hyang, Kim, Sangwoo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.08.2019; Nature Publishing Group
• Subjects: 631/208/514/2254; 631/67/68; 631/67/69; Animals; Comparative analysis; Data Descriptor; DNA sequencing; Dogs - genetics; Environmental factors; Exome; Female; Gene expression; Humanities and Social Sciences; Mammary gland; Mammary Neoplasms, Animal - genetics; multidisciplinary; Pets; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Therapeutic applications; Transcription; Transcriptome; Tumors; Whole Exome Sequencing
• ISSN: 2052-4463; 2052-4463
• DOI: 10.1038/s41597-019-0149-8

Studies of naturally occurring cancers in dogs, which share many genetic and environmental factors with humans, provide valuable information as a comparative model for studying the mechanisms of human cancer pathogenesis. While individual and small-scale studies of canine cancers are underway, more generalized multi-omics studies have not been attempted due to the lack of large-scale and well-controlled genomic data. Here, we produced reliable whole-exome and whole-transcriptome sequencing data of 197 canine mammary cancers and their matched controls, annotated with rich clinical and biological features. Our dataset provides useful reference points for comparative analysis with human cancers and for developing novel diagnostic and therapeutic technologies for cancers in pet dogs. Design Type(s) disease state design • transcription profiling design • parallel group design Measurement Type(s) transcription profiling assay • exome Technology Type(s) RNA sequencing • DNA sequencing Factor Type(s) breed • age • experimental condition • diagnosis Sample Characteristic(s) Canis lupus familiaris • tissue Machine-accessible metadata file describing the reported data (ISA-Tab format)