The many secret lives of adipocytes: implications for diabetes

Adipose tissue remains a cryptic organ. The ubiquitous presence of adipocytes, the different fat pads in distinct anatomical locations, the many different types of fat, in each case with their distinct precursor populations, and the ability to interchange into other types of fat cells or even de-dif...

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Bibliographic Details
Published inDiabetologia Vol. 62; no. 2; pp. 223 - 232
Main Author Scherer, Philipp E.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019
Springer Nature B.V
Subjects
Adipocytes
Adipocytes - metabolism
Adipokines - metabolism
Adipose tissue
Adipose Tissue - metabolism
Animals
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Energy Metabolism - physiology
Homeostasis
Human Physiology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Obesity - metabolism
Review
Vascularisation
De-differentiation
Fibrosis
Ceramides
Inflammation
Sphingolipids
Review
Adipokines
Exosomes
Adiponectin
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Summary:Adipose tissue remains a cryptic organ. The ubiquitous presence of adipocytes, the different fat pads in distinct anatomical locations, the many different types of fat, in each case with their distinct precursor populations, and the ability to interchange into other types of fat cells or even de-differentiate altogether, offers a staggering amount of complexity to the adipose tissue organ as a whole. Adipose tissue holds the key to improving our understanding of systemic metabolic homeostasis. As such, understanding adipose tissue physiology offers the basis for a mechanistic understanding of the pathophysiology of diabetes. This review presents some of the lesser known aspects of this fascinating tissue, which consistently still offers much opportunity for the discovery of novel targets for pharmacological intervention.
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Contribution statement
PES is responsible for the conceptualisation and writing of this manuscript and is the sole contributor.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-018-4777-x