Effects of sodium diclofenac on the concentration function in animals with different neurohypophyseal status
The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with...
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| Published in | Bulletin of experimental biology and medicine Vol. 152; no. 6; pp. 728 - 730 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English Russian |
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Boston
Springer US
01.04.2012
Springer Springer Nature B.V |
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| Abstract | The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed. |
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| AbstractList | The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed.[PUBLICATION ABSTRACT] The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed. The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed. Key Words: diclofenac; osmotic concentration; Brattleboro rats |
| Audience | Academic |
| Author | Ivanova, L. N. Babina, A. V. Shestopalova, L. V. Beizel, N. F. Lavrinenko, V. A. |
| Author_xml | – sequence: 1 givenname: V. A. surname: Lavrinenko fullname: Lavrinenko, V. A. email: igor@academ.org organization: Novosibirsk State University – sequence: 2 givenname: A. V. surname: Babina fullname: Babina, A. V. organization: Novosibirsk State University – sequence: 3 givenname: L. V. surname: Shestopalova fullname: Shestopalova, L. V. organization: Novosibirsk State University – sequence: 4 givenname: N. F. surname: Beizel fullname: Beizel, N. F. organization: Novosibirsk State University – sequence: 5 givenname: L. N. surname: Ivanova fullname: Ivanova, L. N. organization: Novosibirsk State University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22803175$$D View this record in MEDLINE/PubMed |
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| References_xml | – volume: 102 start-page: 194 issue: 1 year: 1998 ident: 1617_CR3 publication-title: J. Clin. Invest. doi: 10.1172/JCI2872 contributor: fullname: Y Guan – volume: 289 start-page: R1238 issue: 5 year: 2005 ident: 1617_CR9 publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00182.2005 contributor: fullname: EM Stricker – volume: 279 start-page: F12 issue: 1 year: 2000 ident: 1617_CR1 publication-title: Am. J. Renal Physiol. doi: 10.1152/ajprenal.2000.279.1.F12 contributor: fullname: MD Breyer – volume: 63 start-page: 579 year: 2001 ident: 1617_CR2 publication-title: Ann. Rev. Physiol. doi: 10.1146/annurev.physiol.63.1.579 contributor: fullname: MD Breyer – volume: 287 start-page: F816 issue: 4 year: 2004 ident: 1617_CR6 publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00398.2003 contributor: fullname: AT Layton – volume: 35 start-page: 299 issue: 5 year: 1983 ident: 1617_CR4 publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1983.tb02938.x contributor: fullname: J Haylor – volume: 277 start-page: F1 issue: 1, Pt. 2 year: 1999 ident: 1617_CR11 publication-title: Ibid. contributor: fullname: T Yang – volume: 274 start-page: F413 issue: 2, Pt. 2 year: 1998 ident: 1617_CR10 publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.1998.274.2.F413 contributor: fullname: X Wang – volume: 265 start-page: F643 issue: 5, Pt. 2 year: 1993 ident: 1617_CR5 publication-title: Am. J. Physiol. contributor: fullname: RL Hebert – volume: 279 start-page: F294 issue: 2 year: 2000 ident: 1617_CR8 publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.2000.279.2.F294 contributor: fullname: AJ Rouch – volume: 1 start-page: 30 issue: 1 year: 2001 ident: 1617_CR7 publication-title: Mol. Interv. contributor: fullname: IA Mardini |
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| SubjectTerms | Animals Anti-inflammatory drugs Biomedical and Life Sciences Biomedicine Cations, Monovalent Cell Biology Cyclooxygenase Inhibitors - administration & dosage Diclofenac - administration & dosage Internal Medicine Kidney - drug effects Kidney - metabolism Kidney - physiopathology Laboratory Medicine Osmolar Concentration Pathology Pituitary Gland, Posterior - drug effects Pituitary Gland, Posterior - metabolism Pituitary Gland, Posterior - physiopathology Pituitary hormones Prostaglandin Antagonists - administration & dosage Prostaglandins - metabolism Rats Rats, Brattleboro Rats, Wistar Sodium - urine Urea Urea - urine Vasopressins - deficiency Vasopressins - genetics Water-Electrolyte Balance - drug effects |
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| Title | Effects of sodium diclofenac on the concentration function in animals with different neurohypophyseal status |
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