Effects of sodium diclofenac on the concentration function in animals with different neurohypophyseal status

• Published in: Bulletin of experimental biology and medicine Vol. 152; no. 6; pp. 728 - 730
• Main Authors: Lavrinenko, V. A., Babina, A. V., Shestopalova, L. V., Beizel, N. F., Ivanova, L. N.
• Format: Journal Article
• Language: English; Russian
• Published: Boston Springer US 01.04.2012; Springer; Springer Nature B.V
• Subjects: Animals; Anti-inflammatory drugs; Biomedical and Life Sciences; Biomedicine; Cations, Monovalent; Cell Biology; Cyclooxygenase Inhibitors - administration & dosage; Diclofenac - administration & dosage; Internal Medicine; Kidney - drug effects; Kidney - metabolism; Kidney - physiopathology; Laboratory Medicine; Osmolar Concentration; Pathology; Pituitary Gland, Posterior - drug effects; Pituitary Gland, Posterior - metabolism; Pituitary Gland, Posterior - physiopathology; Pituitary hormones; Prostaglandin Antagonists - administration & dosage; Prostaglandins - metabolism; Rats; Rats, Brattleboro; Rats, Wistar; Sodium - urine; Urea; Urea - urine; Vasopressins - deficiency; Vasopressins - genetics; Water-Electrolyte Balance - drug effects; Brattleboro rats; osmotic concentration; diclofenac
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1617-8

The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed.