Mitochondria-Targeted and Resveratrol-Loaded Dual-Function Titanium Disulfide Nanosheets for Photothermal-Triggered Tumor Chemotherapy

• Published in: Nanoscale research letters Vol. 14; no. 1; pp. 211 - 10
• Main Authors: Xiang, Sen, Zhang, Kaifang, Yang, Guanghua, Gao, Dongdong, Zeng, Chen, He, Miao
• Format: Journal Article
• Language: English
• Published: New York Springer US 21.06.2019; Springer Nature B.V; SpringerOpen
• Subjects: Anticancer properties; Apoptosis; Biocompatibility; Cancer; Caspase; Chemistry and Materials Science; Chemotherapy; Conjugation; Cytochrome; Cytochrome c; Cytochromes; Drug delivery; Drug delivery systems; I.R. radiation; In vivo methods and tests; Iodides; IR780 iodide; Irradiation; Materials Science; Membrane potential; Mitochondria; Mitochondria target; Molecular Medicine; Nano Express; Nanochemistry; Nanocomposites; Nanoscale Science and Technology; Nanosheets; Nanotechnology; Nanotechnology and Microengineering; NIR-triggered chemotherapy; Resveratrol; Surgical implants; Titanium; Titanium disulfide; Toxicity; Tumors; Mitochondria target; Titanium disulfide; NIR-triggered chemotherapy; IR780 iodide; Apoptosis
• ISSN: 1931-7573; 1556-276X
• DOI: 10.1186/s11671-019-3044-5

A subcellular organelle-targeted delivery of anti-cancer drugs is a promising strategy to maximize the anti-cancer effects and minimize the adverse effects. Herein, we prepared a mitochondria-targeted drug delivery nanoplatform based on IR780 iodide (IR780) and titanium disulfide (TiS 2 ) nanosheets. Due to the large specific surface area of TiS 2 nanosheets, the nanoplatform could highly load anti-cancer drug resveratrol (RV). The as-prepared nanocomposite (IR780-TiS 2 /RV) was used for an efficacious photothermal-triggered tumor chemotherapy. IR780-TiS 2 /RV showed satisfactory stability and biocompatibility, and the loading ratio of RV and IR780 was about 112% and 56%, respectively. Upon the near-infrared (NIR) irradiation, the heat generated by IR780-TiS 2 /RV could trigger the RV release. Due to the conjugation with the mitochondria-specific IR780, IR780-TiS 2 /RV could target and accumulate in mitochondria and release RV when triggered by NIR to decrease the mitochondrial membrane potential, rapidly induce the upregulation of key intrinsic apoptotic factors such as cytochrome c, and initiate the caspase cascade, thereby achieving the chemotherapeutic effect. The IR780-TiS 2 /RV nanocomposite was demonstrated to have a high anti-tumor efficacy in vitro and in vivo as well as no remarkable tissue toxicity. We believe our study demonstrates that the NIR-triggered IR780-TiS 2 /RV nanoplatform could be a promising chemotherapeutic agent in clinical practice.