Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 9; pp. 3919 - 3928
• Main Authors: Kyle, J. E., Burnum-Johnson, K. E., Wendler, J. P., Eisfeld, A. J., Halfmann, Peter J., Watanabe, Tokiko, Sahr, Foday, Smith, R. D., Kawaoka, Y., Waters, K. M., Metz, T. O.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.02.2019
• Series: PNAS Plus
• Subjects: 60 APPLIED LIFE SCIENCES; Adolescent; Adult; Apoptosis; Autophagy; Biological Sciences; Blood plasma; Child; critical illness; Critical Illness - epidemiology; Disease Outbreaks; Ebola; Ebola virus; Ebolavirus; Ebolavirus - genetics; Ebolavirus - pathogenicity; Energy sources; Epidemics; Female; Gene Expression Regulation - genetics; Hemorrhagic Fever, Ebola - blood; Hemorrhagic Fever, Ebola - genetics; Hemorrhagic Fever, Ebola - pathology; Hemorrhagic Fever, Ebola - virology; Humans; Illnesses; Lipid Metabolism - genetics; lipidomics; Lipids; Lipids - blood; Lipids - genetics; Liver; Liver diseases; Male; mass spectrometry; Outbreaks; Phagocytosis; PNAS Plus; Recovery; Sierra Leone - epidemiology; Survival; Target recognition; therapies; Viral diseases; Viremia; Young Adult; Sierra Leone; mass spectrometry; therapies; critical illness; Ebola; lipidomics

Ebola virus disease (EVD) often leads to severe and fatal outcomes in humans with early supportive care increasing the chances of survival. Profiling the human plasma lipidome provides insight into critical illness as well as diseased states, as lipids have essential roles as membrane structural com...